Baseceuticals is the premier global biotech company which has confidence to provide adeno-associated viral vector service for gene delivery in an efficient way. We have a team of passionate and talented scientists who have a wealth of knowledge and extensive experience in gene delivery vectors. In addition, relying on our proprietary technologies and mature platform, we offer comprehensive adeno-associated viral vector service for global customers to meet customers' needs in basic research and preclinical application. Baseceuticals is your reliable partner and work closely with you to accelerate the project progress.
Adeno-associated viruses (AAVs) have become essential therapeutic gene delivery vectors. Adeno associated virus belongs to the parvoviridae family with an icosahedral symmetry morphology, and comprises a ~ 5 kb single-stranded deoxyribonucleic acid (DNA) genome with two inverted terminal repeats (ITRs) on both ends and flanked by two open reading frames (ORFs). One is structural rep gene indicating AAV life cycle required proteins and the other is packaging cap gene for capsid proteins.
Fig. 1 Schematic representation of the basic components of a gene insert packaged inside recombinant AAV gene transfer vector
The AAVs are popular gene delivery vectors because they are able to package and express foreign genes in a broad range of tissues. AAV vectors are non-pathogenic, eliciting little immune response and having potentials for long-lasting transgene expression in both quiescent and dividing cells, therefore, they are recognized as one of the major delivery vectors for research and gene therapy applications. In addition, recombinant AAVs can be manufactured and purified at a high titer, making them available for clinical use. There are gene therapy commercial products in the market such as Glybera® with AAV1, Luxturna® with AAV2 and Zolgensma® with AAV9.
Fig. 2 Cell entry and trafficking of the adeno-associated virus (AAV) vector
Highly efficient tailor-made AAV vector design and construction services with justifiable cost are provided by Baseceuticals' highly experienced teams. Different adeno-associated viral vectors are available for shRNA, human ORF cloning according to the different needs of customers. High GC content, large and highly repetitive sequences can be addressed in our excellent platform.
Baseceuticals furnishes AAV capsid serotype selection services to ensure optimal gene delivery with a list below of our suggested AAV serotypes for different tissue types. If you are unsure about which AAV serotype could best fit your project, please contact our experts for advice on your selection.
Baseceuticals provide recombinant AAV vector packaging services based on the plasmid-mediated delivery into packing cell lines. After gradient ultracentrifugation, purification and RT-qPCR-determined titering, recombinant AAV vector particles are ready-to-use for in vitro or in vivo gene therapy applications.
Baseceuticals provides comprehensive adeno-associated viral vector services from vector design and construction to GMP production for clinical applications. Our talent experts will propose the best strategy to customers depending on the advanced technologies and years of experience. Based on the commitment of prompt communication and on-time reporting, our researchers will ensure the high-efficiency services to meet the strict project timelines. If you have any additional requirements or questions, please do not hesitate to contact us at . Our expert team is pleased to assist you in every way we can.
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