Gene Editing

Gene Editing

As one of a world-renowned biotechnology company, Baseceuticals offers the best gene editing service to the global customers. We establish an excellent and efficient gene editing system to adapt the rapidly evolving needs of gene therapy. Based on the most advanced gene editing technologies and facilities, our experienced staffs manipulate the organism's DNA sequence precisely to achieve a therapeutic effect. At Baseceuticals, we provide one-stop gene editing service with high quality and high efficiency to meet your various needs. We will work closely with you to help you achieve the research goals in the shortest time.

Gene editing is a technology which can produce genome modifications, such as targeted mutagenesis or site-directed insertion/deletion/substitution, at specific sites in the genome of living organisms. Gene editing relies on the production of site-specific double-strand DNA breaks (DSBs) and the subsequent endogenous repair through the error-prone non-homologous end-joining (NHEJ) or the error-free homology-directed repair (HDR) pathways. So far, zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) are the three primary genome editing tools used to produce site specific DSBs, but they are different in editing efficiency, off-target efficiency, delivery strategy and manipulation difficulty. The following table is the comparison of the three types of gene editing tools, which one to be chosen depends on your specific research purpose.

ZFNsTALENsCRISPR/Cas9
Specificity18-36nt30-36nt23nt
Efficiencylowmoderatehigher
manipulation difficultylaboriouslaborioussimple
Costvery expensiveexpensivecheap
multiplex editingdifficulteasyeasy
off-target efficiencylowlowhigher

The advent of gene editing technologies has enabled a new paradigm in gene therapy that the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences.

Overview of gene editingFig.1 Overview of gene editing

Applications of Gene Editing

  • Gene therapy
  • Cancer research
  • Mouse models
  • sgRNA library
  • Synthetic biology

Contents of Gene Editing Service

At Baseceuticals, we mainly provide customizable and flexible gene editing service through ZFN, TALEN, CRISPR/Cas9 technologies to support your research projects. For genetically-defined diseases, we can use the programmable nucleases to cut DNA at a specific site in a disease-causing gene, to ameliorate the genetic defect through gene disruption or correction. For cell therapies, we can target genes that when disrupted may improve the safety or efficacy of the therapy, or precisely insert new genes to give the cells new abilities.

Advantages of Gene Editing Service in Baseceuticals

  • Quick response and superior service
  • Excellent and efficient gene editing system
  • Multiple service types are available for gene editing
  • Precise editing to every base pair with high efficiency
  • Fast turnaround time
  • Cost-effective

Baseceuticals is specializing in building efficient systems and procedures to meet the demands and timelines of clients working in the gene editing. We guarantee to provide high-quality and comprehensive gene editing service with the most competitive price. For further information, please do not hesitate to contact us at or 1-631-626-9181.

Reference

  1. Kim, E. J., Kang, K. H., & Ju, J. H. (2017). CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells. The Korean Journal of Internal Medicine, 32(1), 42–61.

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