Gene Silencing

Gene Silencing

As one of the top companies in genetic modification filed, Baseceuticals are proud to provide comprehensive gene silencing services for customers worldwide. Based on the outstanding platform, our experienced technical staffs have developed best-in-class technologies to complete a variety of gene silencing projects with satisfaction guaranteed. We mainly use RNA interference and antisense oligonucleotide methods for gene silencing to meet your various needs. Our research team will cooperate with you closely, assisting you to achieve the research goal.

Gene silencing is a natural cellular phenomenon, implements blocking by causing degradation of the intermediate RNA form before the RNA code can be translated into a protein. The most commonly used methods of gene silencing are RNA interference (RNAi) and antisense oligonucleotide (ASO) technologies. These two methods have proven their potentials for gene therapy applications, offering great promise for curing diseases and drug research.

Fig.1 Gene  silencing mechanisms of siRNA and miRNAFig.1 Gene silencing mechanisms of siRNA and miRNA

Genetic therapies can be separated into three types, namely short synthetic nucleotides, virus-mediated gene therapy and genomic DNA editing/engineering. RNAi and ASOs are the examples of short synthetic nucleotides. RNAi-based and ASOs-based therapies are synthetic strands of nucleotides bind individual RNAs through canonical Watson-Crick base pairing. However, these two methods have different mechanisms. The mechanisms of action for ASOs are through degrading RNA, blocking protein translation and modifying RNA splicing. As to the RNAi-based therapy, it works through the RNA-induced silencing complex (RISC)-mediated cleavage of messenger RNA to prevent the formation of the proteins that they code for.

Fig.2 Antisense  oligonucleotides (ASOs) vs RNA interference (RNAi)Fig.2 Antisense oligonucleotides (ASOs) vs RNA interference (RNAi)

Advantages of Gene Silencing Service

  • Professional team with years of experience in gene silencing
  • State-of-the-art platform with advanced technology
  • High silencing efficiency with trusted and reliable results
  • Give progress feedbacks with short turnaround time
  • Provide customized services
  • Reasonable price

Baseceuticals is the premier institution to provide professional gene silencing service. At Baseceuticals, we are specializing in developing efficient systems and methods to meet various requirements of customers working in gene silencing. With years of experience, we have confidence in offering you reliable and precise results in gene silencing. Our dedicated teams are pleased to offer an individual solution for you and update the progress of each step promptly. Baseceuticals has always been your dependable research partner, and we are waiting for your interesting projects. If you have any questions, please do not hesitate to contact us at or 1-631-626-9181. 

References:

  1. Lam, J. K. W., Chow, M. Y. T., Zhang, Y., & Leung, S. W. S.. (2015). siRNA versus miRNA as therapeutics for gene silencing. Molecular Therapy—Nucleic Acids, 4(9), e252.
  2. Rossor, A. M., Reilly, M. M., & Sleigh, J. N.. (2018). Antisense oligonucleotides and other genetic therapies made simple. Practical Neurology, 18(2), 126–131. 

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