Lentiviral Vector Service

Lentiviral Vector Service

As one of the leading providers in gene delivery field, Baseceuticals provides comprehensive lentiviral vector service. Our service is backed by excellent researchers, advanced technologies and state-of-the-art facilities. Based on the years of experience, our researchers have succeeded in numerous lentiviral vector projects, including but not limit to lentiviral vector design, construction and packaging. To meet different needs, we have developed customized service. Our lentiviral vector service can significantly assist customers in gene therapy by offering high-quality and high-confidence results.

Gene therapy using lentiviral vectors has appeared as a promising therapeutic selection for several conditions. Lentivirus is a subgroup of the retroviridae family, and it has the capability of delivering large amount of genetic materials to both dividing and non-dividing cells. In regulation of replicative functions, the 3 to 9 kb single stranded RNA genome with long-inverted terminal repeats (LTRs) at both ends, and flanked by lentiviral genes gag-pol-env codes, and accessory genes depending on the virus was involved.

Lentivirus is characterized by a long incubation period, providing relatively long-lasting changed gene expression in host cells for up to six months. In addition, lentiviruses can deliver a great deal of genetic information into the DNA of the host cell and have large packaging capacity (~ 8 kb). Based on these attractive features, the use of lentiviral vectors has been increasing and they are regarded as one of the most efficient methods of a gene delivery vector for gene therapy.

Third-generation lentiviral vectorFig. 1 Third-generation lentiviral vector

Lentiviral Vector Service Includes

  • Custom lentiviral vector design and construction

Baseceuticals are ready to offer custom lentiviral vector design and construction service. We are expertized on difficult cloning projects such as large, toxic, highly repetitive sequences or high GC content clones etc. The cost is reasonable and the turnaround time is short.

  • Recombinant lentiviral vector packaging

Recombinant lentiviral vector packaging service refers to modified genomes with therapeutic genetic cargos (TGC) are delivered into the packaging cell lines. In addition, gag/pol, rev, VSV-G and other essential genes are also plasmid-mediated transfected and expressed related proteins to form lentiviral particles. They are ready-to-use for in vitro and in vivo applications after sucrose gradient ultracentrifugation, purification and RT-qPCR-determined titering etc.

Workflow

Lentiviral Vector Service

Our Features of Lentiviral Vector Service

  • Professional research team with wealthy knowledge
  • Years of experience in lentiviral vector projects
  • Excellent and mature experimental platform
  • Fast turnaround time with reliable results
  • Provide customized service according to the specific needs
  • Reasonable price

Baseceuticals has confidence in providing lentiviral vector service to global customers. Tell us your project needs, we will offer you one-stop satisfactory service. We guarantee our clients the most reliable and efficient service to greatly accelerate the project progress with the faster turnaround time and lower price. Once the project begins, we will work closely with you and make an update regularly to strictly meet your timeline. Baseceuticals is your reliable partner for your research at all time. For further information about lentiviral vector service, please do not hesitate to contact us at or 1-631-626-9181.

Reference

  1. Milone, M. C. , & Una O'Doherty. (2018). Clinical use of lentiviral vectors. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 32(7), 1.

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