RNAi Service

RNAi Service

As a leading provider of gene silencing service, Baseceuticals is proud to offer high quality RNAi service for customers worldwide. Our talented researchers have established a mature and comprehensive platform to develop the advanced technologies to offer the reliable results at the most competitive price. We have assembled a professional research team with years of experience and wealthy knowledge in RNAi. We will put forward the best strategy for your projects after communication of the specific situation. At Baseceuticals, we are working with you closely to rapidly move forward the projects.

RNA interference (RNAi) is a biological procedure that gene expression or translation is restrained by targeted mRNA molecules. The mechanism of RNAi includes initiation and effector steps. Firstly, the dsRNA is recognized and cleaved into siRNAs with a length of 21-23 nucleotides by Dicer. Then these siRNAs are integrated into a RNA-induced silencing complex (RISC), which acts on the cognate mRNA and degrades it. The RNAi mechanism for sequence-specific gene silencing has essential applications in therapeutic intervention and target identification of drug discovery. RNAi has been regarded as a therapeutic method for disease treatment, such as the treatment of age-related macular degeneration. Other therapies based on RNAi are being developed for viral infection, treatment of neurodegenerative diseases and cancers.

RNAi mechanism. Differences between siRNA, shRNA, and miRNA as therapeutic tools. Fig.1 RNAi mechanism. Differences between siRNA, shRNA, and miRNA as therapeutic tools.

Contents of Baseceuticals RNAi Service

  • siRNA/shRNA design and synthesis
  • shRNA vector construction
  • siRNA/shRNA transfection
  • RNAi effect test by RT-PCR and western blot
  • Custom lentivirus-mediated RNAi service including custom lentiviral particles and cell lines

We provide a one-stop RNAi service to customers or you can select some services based on the specific needs.

Our service will promise to provide:

  1. Complete experimental report, including detailed experimental procedures, siRNA/shRNA sequence, sequencing report for vector, test results, gel pictures, etc.
  2. Experimental products (if applicable), such as constructed vectors.

Advantages of RNAi Service in Baseceuticals

  • One stop services from siRNA/shRNA design to RNAi effect test
  • Dedicated PhD-level technical support during the entire process
  • Competitive price with satisfaction guaranteed
  • Mature and excellent platform
  • Years of experience in RNAi projects
  • Rapid turnaround time
  • Provide customized services

As a premier company in gene therapy, Baseceuticals has extensive experience in using RNAi as a therapeutic method to treat diseases, increasing value to your projects. We can provide multiple strategies coving the entire process of using the RNAi, including siRNA/shRNA design, vector construction, transfection and so on. Our dedicated PhD level staffs will provide technical support throughout the whole process to make sure every step is well-organized and solve your problems. If you have questions about the RNAi service, please do not hesitate to contact us at or 1-631-626-9181.

Reference

  1. Torrecilla, J. , Rodríguez-Gascón, Alicia, Solinís, María ángeles, & del Pozo-Rodríguez, Ana. (2014). Lipid nanoparticles as carriers for RNAi against viral infections: current status and future perspectives. BioMed Research International, 2014, 1-17.

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