Viral Gene Delivery Systems

Viral Gene Delivery Systems

As a leading provider of gene delivery service, Baseceuticals is proud to offer viral gene delivery service with high quality to global customers. Based on the advanced technologies and excellent platform, our researchers have succeeded in a variety of projects related to viral gene delivery systems, including design and construction of viral vectors and large scale production. At Baseceuticals, one stop service is available for viral gene delivery systems for basic research and preclinical applications. Our comprehensive services can significantly assist customers in drug development by offering high-quality and reliable results.

Gene therapy is a promising method to treat genetic and acquired diseases by utilization of the therapeutic delivery of nucleic acid into host cells. The key to success of gene therapy is to create safe and efficient gene delivery systems. Gene delivery systems are categorized as viral gene delivery systems and non-viral gene delivery systems. Among them, viral delivery systems are the most commonly used due to high delivery efficiency. In viral gene delivery systems, viruses are unable to replicate through redesigning, but can deliver the genes to the cells to provide expression. Viral systems have advantages such as high efficiency, low toxicity, cell type specificity, constant expression, dominating the clinical trials in gene therapy. On the current gene therapy market, the major delivery system of approved products are viral vectors, such as Yescarta® with retrovirus, Gendicine® with adenovirus, Glybera®, Luxturna® and Zolgensma® with adeno-associated viruses.

Fig.1 Schematic of Gene Therapy with Viral  VectorsFig.1 Schematic of Gene Therapy with Viral Vectors

The retrovirus, adenovirus, adeno-associated virus, lentivirus and other viruses like herpes simplex virus are widely used in gene therapy applications. A comparison of different viral vectors is illustrated below to overview their advantages and disadvantages in gene delivery.

Viral vectorsRetrovirusAdenovirusAdeno-associate virusLentivirusHerpes simplex virus
GenomessRNAdsDNAssDNAssRNAdsDNA
Genome Size7-10kb36-38kb5kb3-9kb130-280kb
Viron Diameter80-130nm70-90nm18-26nm80-130nm150-200nm
CoatEnvelopedNakedNakedEnvelopedEnveloped
InfectivityDividing cellsDividing and non-dividing cellsDividing and non-dividing cellsDividing and non-dividing cellsDividing and non-dividing cells
Packaging Capability8kb7.5kb4.5kb8kb>30kb
Transduction EfficiencyModerateHighModerateModerateModerate
Host Genome IntegrationYesNoNoYesNo
Transgene ExpressionStableTransientPotential long lastingStableTransient
ImmuogenicityModerateHighVery lowLowModerate

Contents of Viral Gene Delivery Systems in Baseceuticals

We provide assorted tailored viral vectors for gene therapy, including but not limited to:

  • Adenoviral vectors
  • Lentiviral vectors
  • Retroviral vectors
  • Adeno-associate virus vectors
  • Herpes simplex virus vectors
  • Vaccinia viral vectors
  • Other Viral Vectors

Our Advantages

  • Free consultation of using gene delivery systems for gene therapy
  • Years of experience
  • Professional research team
  • Outstanding platforms in compliance with GMP regulations
  • Multiple virus types are available for gene delivery
  • Competitive price

As a global leader, Baseceuticals has confidence in offering you the affordable and reliable service for viral gene delivery systems to accelerate the project progress. In addition, we assembled a professional and experienced team to provide consultation of using gene delivery systems for gene therapy. For more information, please feel free to contact us at any time. Our technicians will service you to provide the most detailed solutions to your inquires.

Reference

  1. Sapolsky, R. M. (2003). Gene Therapy for Psychiatric Disorders. American Journal of Psychiatry, 160(2), 208–220. 

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